HORDB

ID: hor001680
Uniprot ID: P42565
Protein name: SDPYLRF-amide
Gene name: NA
Organism: Lymnaea stagnalis (Great pond snail) (Helix stagnalis)
Family: FARP (FMRFamide related peptide) family
Source: animal
Expression: Expressed in 57 cells including a cardiorespiratory cell and the visceral white interneuron (VWI).
Disease: NA
Comments: NA
Taxonomy: Lymnaea (genus), Lymnaeidae (family), Lymnaeoidea (superfamily), Hygrophila, Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: SDPYLRF
Length: 7
Propeptide: MKTWSHVALLACLSIKWLTCVMADSIYCDDPDMCSNSVDLDRKEFFPLGRHDGVYQTPEEDGDLEDRQTRGDPFLRFGRGDPFLRFGRGDPFLRFGRGDPFLRFGQSDPFLRFGRGDPFLRFGRGDPFLRFGKSDPFLRFGRSDPFLRFGRSDPFLRFGKSDPFLRFGKSDPFLRFGKSDPYLRFGRGDPFLRFGRSDPFFRFGKQQVATDDSGELDDEILSRVSDDDKNIRRKRSTDSAENAHTRHEREASAPRAKGKVGEVKSSDDFQSREIRSKPYMRFGRNNLNNYALEDEDCKLTSDIIDDQFQRYQRGPSRSSFPRYGKRQDKRHDYMRFGRTSGGDFMGYDKSPENVGAEQSR
Signal peptide: MKTWSHVALLACLSIKWLTCVMADSIYCDDPDMCS
Modification: T7 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001680_AF2.pdb

hor001680_ESM.pdb

Mass:	100419	Formula:	C42H60N10O12
Absent amino acids:	ACEGHIKMNQTVW	Common amino acids:	DFLPRSY
pI:	6.34	Basic residues:	1
Polar residues:	2	Hydrophobic residues:	2
Hydrophobicity:	-72.86	Boman Index:	-1928
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	55.71
Instability Index:	3608.57	Extinction Coefficient cystines:	1490
Absorbance 280nm:	248.33

PubMed ID: 2002360
Title: Neuropeptides Gly-Asp-Pro-Phe-Leu-Arg-Phe-amide (GDPFLRFamide) and Ser-Asp-Pro-Phe-Leu-Arg-Phe-amide (SDPFLRFamide) are encoded by an exon 3' to Phe-Met-Arg-Phe-NH2 (FMRFamide) in the snail Lymnaea stagnalis.